First published May 8, 2014 - More info
A complex biologic network regulates kidney perfusion under physiologic conditions. This system is profoundly perturbed following renal ischemia, a leading cause of acute kidney injury (AKI) — a life-threatening condition that frequently complicates the care of hospitalized patients. Therapeutic approaches to prevent and treat AKI are extremely limited. Better understanding of the molecular pathways promoting postischemic reflow could provide new candidate targets for AKI therapeutics. Due to its role in adapting tissues to hypoxia, we hypothesized that extracellular adenosine has a regulatory function in the postischemic control of renal perfusion. Consistent with the notion that equilibrative nucleoside transporters (ENTs) terminate adenosine signaling, we observed that pharmacologic ENT inhibition in mice elevated renal adenosine levels and dampened AKI. Deletion of the ENTs resulted in selective protection in
Almut Grenz, Jessica D. Bauerle, Julee H. Dalton, Douglas Ridyard, Alexander Badulak, Eunyoung Tak, Eóin N. McNamee, Eric Clambey, Radu Moldovan, German Reyes, Jost Klawitter, Kelly Ambler, Kristann Magee, Uwe Christians, Kelley S. Brodsky, Katya Ravid, Doo-Sup Choi, Jiaming Wen, Dmitriy Lukashev, Michael R. Blackburn, Hartmut Osswald, Imogen R. Coe, Bernd Nürnberg, Volker H. Haase, Yang Xia, Michail Sitkovsky, Holger K. Eltzschig
Original citation: J. Clin. Invest. 2012;122(2):693–710. doi:10.1172/JCI60214.
Citation for this expression of concern: J. Clin. Invest. 2014;124(6):2807. doi:10.1172/JCI76888.
The Editorial Board has recently obtained information regarding duplicate use of histology images in the 2012 article reporting ENT1 regulation of postischemic blood flow during acute kidney injury by Grenz et al. Our evaluation suggests that Figure 5H (WT –I) is duplicated in Figure 7I (–I –DIP); Figure 5H (Ent1–/– –I) is duplicated in Figure 7D (+I +DIP) and again in Figure 8I (–I –DIP) and again in Supplemental Figure 8G (WT –I); Figure 7I (–I +DIP) is duplicated in Figure 7N (–I +DIP); and Figure 9D (–I –DIP) is duplicated in Figure 9I (–I +DIP). Because the authors have used the same images to represent different experiments, different treatment protocols, and mice of different genotypes, the Editorial Board is pursuing further investigation of this matter. We will inform our readers of the outcome when the investigation is complete.