[HTML][HTML] Transient receptor potential mucolipin 1 (TRPML1) and two-pore channels are functionally independent organellar ion channels
S Yamaguchi, A Jha, Q Li, AA Soyombo… - Journal of Biological …, 2011 - ASBMB
NAADP is a potent second messenger that mobilizes Ca 2+ from acidic organelles such as
endosomes and lysosomes. The molecular basis for Ca 2+ release by NAADP, however, is
uncertain. TRP mucolipins (TRPMLs) and two-pore channels (TPCs) are Ca 2+-permeable
ion channels present within the endolysosomal system. Both have been proposed as targets
for NAADP. In the present study, we probed possible physical and functional association of
these ion channels. Exogenously expressed TRPML1 showed near complete colocalization …
endosomes and lysosomes. The molecular basis for Ca 2+ release by NAADP, however, is
uncertain. TRP mucolipins (TRPMLs) and two-pore channels (TPCs) are Ca 2+-permeable
ion channels present within the endolysosomal system. Both have been proposed as targets
for NAADP. In the present study, we probed possible physical and functional association of
these ion channels. Exogenously expressed TRPML1 showed near complete colocalization …
