Interleukin-22 ameliorates acute-on-chronic liver failure by reprogramming impaired regeneration pathways in mice
Background & Aims Acute-on-chronic liver failure (ACLF) is a clinical syndrome defined by
liver failure on pre-existing chronic liver disease. It is often associated with bacterial infection
and high short-term mortality. Experimental models that fully reproduce ACLF are lacking, so
too are effective pharmacological therapies for this condition. Methods To mimic ACLF
conditions, we developed a severe liver injury model by combining chronic injury (chronic
carbon tetrachloride [CCl 4] injection), acute hepatic insult (injection of a double dose of CCl …
liver failure on pre-existing chronic liver disease. It is often associated with bacterial infection
and high short-term mortality. Experimental models that fully reproduce ACLF are lacking, so
too are effective pharmacological therapies for this condition. Methods To mimic ACLF
conditions, we developed a severe liver injury model by combining chronic injury (chronic
carbon tetrachloride [CCl 4] injection), acute hepatic insult (injection of a double dose of CCl …
