Nongranulomatous interstitial pneumonitis in sarcoidosis: Relationship to development of epithelioid granulomas
Y Rosen, TJ Athanassiades, S Moon, HA Lyons - Chest, 1978 - Elsevier
Nongranulomatous, nonspecific interstitial pneumonitis was a predominating or prominent
histopathologic finding in 62 percent of 128 granuloma-containing specimens from open
lung biopsies obtained from patients with sarcoidosis. Data from this study, combined with
observations by others on the evolution of experimentally induced granulomas, indicate that
interstitial pneumonitis represents a very early lesion, possibly the initial lesion, in
pulmonary sarcoidosis. Because of the relatively large error of sampling inherent in the …
histopathologic finding in 62 percent of 128 granuloma-containing specimens from open
lung biopsies obtained from patients with sarcoidosis. Data from this study, combined with
observations by others on the evolution of experimentally induced granulomas, indicate that
interstitial pneumonitis represents a very early lesion, possibly the initial lesion, in
pulmonary sarcoidosis. Because of the relatively large error of sampling inherent in the …