Regulatory T cells with reduced repressor capacities are extensively amplified in pulmonary sarcoid lesions and sustain granuloma formation
G Rappl, S Pabst, D Riemann, A Schmidt… - Clinical …, 2011 - Elsevier
Sarcoidosis can evolve into a chronic disease with persistent granulomas accompanied by
progressive fibrosis. While an unlimited inflammatory response suggests an impaired
immune control in sarcoid lesions, it stands in contrast to the massive infiltration with CD4+
CD25 high FoxP3+ regulatory T cells. We here revealed that those Treg cells in affected
lung lesions were mainly derived from activated natural Treg cells with GARP (LRRC32)-
positive phenotype but exhibited reduced repressor capacities despite high IL-10 and TGF …
progressive fibrosis. While an unlimited inflammatory response suggests an impaired
immune control in sarcoid lesions, it stands in contrast to the massive infiltration with CD4+
CD25 high FoxP3+ regulatory T cells. We here revealed that those Treg cells in affected
lung lesions were mainly derived from activated natural Treg cells with GARP (LRRC32)-
positive phenotype but exhibited reduced repressor capacities despite high IL-10 and TGF …