[HTML][HTML] Molecular regulation of matrix extracellular phosphoglycoprotein expression by bone morphogenetic protein-2
YD Cho, WJ Yoon, KM Woo, JH Baek, G Lee… - Journal of biological …, 2009 - ASBMB
Matrix extracellular phosphoglycoprotein (MEPE) is mainly expressed in mineralizing
tissues, and its C-terminal proteolytic cleavage product is an acidic-serine-asparate-rich-
MEPE-associated motif (ASARM) that is a strong regulator of body phosphate metabolism
and mineralization. There is sufficient data supporting a role for MEPE protein function in
mineralization, however, little is known about the regulation of MEPE gene expression. As
bone morphogenetic protein-2 (BMP-2) is one of the most important signals for calvarial …
tissues, and its C-terminal proteolytic cleavage product is an acidic-serine-asparate-rich-
MEPE-associated motif (ASARM) that is a strong regulator of body phosphate metabolism
and mineralization. There is sufficient data supporting a role for MEPE protein function in
mineralization, however, little is known about the regulation of MEPE gene expression. As
bone morphogenetic protein-2 (BMP-2) is one of the most important signals for calvarial …