[HTML][HTML] Ribosomal RNA gene transcription mediated by the master genome regulator protein CCCTC-binding factor (CTCF) is negatively regulated by the condensin …
K Huang, J Jia, C Wu, M Yao, M Li, J Jin, C Jiang… - Journal of Biological …, 2013 - ASBMB
CCCTC-binding factor (CTCF) is a ubiquitously expressed" master weaver" and plays
multiple functions in the genome, including transcriptional activation/repression, chromatin
insulation, imprinting, X chromosome inactivation, and high-order chromatin organization. It
has been shown that CTCF facilitates the recruitment of the upstream binding factor onto
ribosomal DNA (rDNA) and regulates the local epigenetic state of rDNA repeats. However,
the mechanism by which CTCF modulates rRNA gene transcription has not been well …
multiple functions in the genome, including transcriptional activation/repression, chromatin
insulation, imprinting, X chromosome inactivation, and high-order chromatin organization. It
has been shown that CTCF facilitates the recruitment of the upstream binding factor onto
ribosomal DNA (rDNA) and regulates the local epigenetic state of rDNA repeats. However,
the mechanism by which CTCF modulates rRNA gene transcription has not been well …