[HTML][HTML] The adaptor protein shb binds to tyrosine 1175 in vascular endothelial growth factor (VEGF) receptor-2 and regulates VEGF-dependent cellular migration
K Holmqvist, MJ Cross, C Rolny, R Hägerkvist… - Journal of Biological …, 2004 - ASBMB
Previous studies have shown that the adaptor protein Shb is involved in receptor tyrosine
kinase signaling. In this study, we demonstrate that Shb is phosphorylated in an Src-
dependent manner upon vascular endothelial growth factor (VEGF) stimulation using
porcine aortic endothelial cells expressing the human VEGF receptor 2 (VEGFR-2)(KDR). In
co-immunoprecipitation experiments, we could detect an interaction between Shb and the
VEGFR-2 in human telomerase-immortalized microvascular endothelial cells. Furthermore …
kinase signaling. In this study, we demonstrate that Shb is phosphorylated in an Src-
dependent manner upon vascular endothelial growth factor (VEGF) stimulation using
porcine aortic endothelial cells expressing the human VEGF receptor 2 (VEGFR-2)(KDR). In
co-immunoprecipitation experiments, we could detect an interaction between Shb and the
VEGFR-2 in human telomerase-immortalized microvascular endothelial cells. Furthermore …