[HTML][HTML] Src kinase activates endothelial nitric-oxide synthase by phosphorylating Tyr-83
D Fulton, JE Church, L Ruan, C Li, SG Sood… - Journal of Biological …, 2005 - ASBMB
The endothelial nitric-oxide synthase (eNOS) is regulated in part by serine/threonine
phosphorylation, but eNOS tyrosine phosphorylation is less well understood. In the present
study we have examined the tyrosine phosphorylation of eNOS in bovine aortic endothelial
cells (BAECs) exposed to oxidant stress. Hydrogen peroxide and pervanadate (PV)
treatment stimulates eNOS tyrosine phosphorylation in BAECs. Phosphorylation is blocked
by the Src kinase family inhibitor, 4-amino-5-(4-chlorophenyl)-7-(t-butyl) pyrazolo [3, 4-d] …
phosphorylation, but eNOS tyrosine phosphorylation is less well understood. In the present
study we have examined the tyrosine phosphorylation of eNOS in bovine aortic endothelial
cells (BAECs) exposed to oxidant stress. Hydrogen peroxide and pervanadate (PV)
treatment stimulates eNOS tyrosine phosphorylation in BAECs. Phosphorylation is blocked
by the Src kinase family inhibitor, 4-amino-5-(4-chlorophenyl)-7-(t-butyl) pyrazolo [3, 4-d] …