Nitric oxide (NO) plays a pivotal role in tumorigenesis, particularly with relation to cancer cell
invasion and metastasis. NO can reversibly couple to cysteine thiols to form an S-
nitrosothiol, which regulates the enzymatic activities of target proteins. c-Src is a tyrosine
kinase that promotes cancer cell invasion and metastasis. Interestingly, c-Src can be
activated by NO stimulation. However, mechanisms by which NO stimulates Src kinase
activity have not been elucidated. We report here that NO causes S-nitrosylation of c-Src at …