[HTML][HTML] ABCA1 mediates concurrent cholesterol and phospholipid efflux to apolipoprotein AI
JD Smith, W Le Goff, M Settle, G Brubaker… - Journal of lipid …, 2004 - ASBMB
Prior studies provide data supporting the notion that ATP binding cassette transporter A1
(ABCA1) promotes lipid efflux to extracellular acceptors in a two-step process: first, ABCA1
mediates phospholipid efflux to an apolipoprotein, and second, this apolipoprotein-
phospholipid complex accepts free cholesterol in an ABCA1-independent manner. In the
current study using RAW264. 7 cells, ABCA1-mediated free cholesterol and phospholipid
efflux to apolipoprotein AI (apoA-I) were tightly coupled to each other both temporally and …
(ABCA1) promotes lipid efflux to extracellular acceptors in a two-step process: first, ABCA1
mediates phospholipid efflux to an apolipoprotein, and second, this apolipoprotein-
phospholipid complex accepts free cholesterol in an ABCA1-independent manner. In the
current study using RAW264. 7 cells, ABCA1-mediated free cholesterol and phospholipid
efflux to apolipoprotein AI (apoA-I) were tightly coupled to each other both temporally and …