[HTML][HTML] HDL-apolipoprotein AI exchange is independently associated with cholesterol efflux capacity
MS Borja, KF Ng, A Irwin, J Hong, X Wu, D Isquith… - Journal of lipid …, 2015 - ASBMB
HDL is the primary mediator of cholesterol mobilization from the periphery to the liver via
reverse cholesterol transport (RCT). A critical first step in this process is the uptake of
cholesterol from lipid-loaded macrophages by HDL, a function of HDL inversely associated
with prevalent and incident cardiovascular disease. We hypothesized that the dynamic
ability of HDL to undergo remodeling and exchange of apoA-I is an important and potentially
rate-limiting aspect of RCT. In this study, we investigated the relationship between HDL …
reverse cholesterol transport (RCT). A critical first step in this process is the uptake of
cholesterol from lipid-loaded macrophages by HDL, a function of HDL inversely associated
with prevalent and incident cardiovascular disease. We hypothesized that the dynamic
ability of HDL to undergo remodeling and exchange of apoA-I is an important and potentially
rate-limiting aspect of RCT. In this study, we investigated the relationship between HDL …