[HTML][HTML] ASXL1 mutation in clonal hematopoiesis

T Fujino, T Kitamura - Experimental Hematology, 2020 - Elsevier
Recent advances in DNA sequencing technologies have enhanced our knowledge about
several diseases. Coupled with easy accessibility to blood samples, hematology plays a
leading role in understanding the process of carcinogenesis. Clonal hematopoiesis (CH)
with somatic mutations is observed in at least 10% of people over 65 years of age, without
apparent hematologic disorders. CH is associated with increased risk of hematologic
malignancies, which is indicative of a pre-malignant condition. Therefore, a better …