TET2-driven clonal hematopoiesis and response to canakinumab: an exploratory analysis of the CANTOS randomized clinical trial
EC Svensson, A Madar, CD Campbell, Y He… - JAMA …, 2022 - jamanetwork.com
Importance Clonal hematopoiesis of indeterminate potential (CHIP) is associated with
increased risk of atherosclerotic cardiovascular disease, and mouse experiments suggest
that CHIP related toTet2loss of function in myeloid cells accelerates atherosclerosis via
augmented interleukin (IL) 1β signaling. Objective To assess whether individuals with CHIP
have greater cardiovascular event reduction in response to IL-1β neutralization in the
Canankinumab Anti-inflammatory Thrombosis Outcomes Trial (CANTOS). Design, Setting …
increased risk of atherosclerotic cardiovascular disease, and mouse experiments suggest
that CHIP related toTet2loss of function in myeloid cells accelerates atherosclerosis via
augmented interleukin (IL) 1β signaling. Objective To assess whether individuals with CHIP
have greater cardiovascular event reduction in response to IL-1β neutralization in the
Canankinumab Anti-inflammatory Thrombosis Outcomes Trial (CANTOS). Design, Setting …
