Assessment of blood-brain barrier permeability by intravenous infusion of FITC-labeled albumin in a mouse model of neurodegenerative disease
A Di Pardo, S Castaldo, L Capocci, E Amico… - JoVE (Journal of …, 2017 - jove.com
Disruption of blood-brain barrier (BBB) integrity is a common feature for different
neurological and neurodegenerative diseases. Although the interplay between perturbed
BBB homeostasis and the pathogenesis of brain disorders needs further investigation, the
development and validation of a reliable procedure to accurately detect BBB alterations may
be crucial and represent a useful tool for potentially predicting disease progression and
developing targeted therapeutic strategies. Here, we present an easy and efficient …
neurological and neurodegenerative diseases. Although the interplay between perturbed
BBB homeostasis and the pathogenesis of brain disorders needs further investigation, the
development and validation of a reliable procedure to accurately detect BBB alterations may
be crucial and represent a useful tool for potentially predicting disease progression and
developing targeted therapeutic strategies. Here, we present an easy and efficient …