[HTML][HTML] A collaborative study to establish the 1st WHO International Standard for human cytomegalovirus for nucleic acid amplification technology
JF Fryer, AB Heath, PD Minor, H Kessler, W Rawlinson… - Biologicals, 2016 - Elsevier
Variability in the performance of nucleic acid amplification technology (NAT)-based assays
presents a significant problem in the diagnosis and management of human cytomegalovirus
(HCMV) infections. Here we describe a collaborative study to evaluate the suitability of
candidate reference materials to harmonize HCMV viral load measurements in a wide range
of NAT assays. Candidate materials comprised lyophilized Merlin virus, liquid Merlin virus,
liquid AD169 virus, and purified HCMV Merlin DNA cloned into a bacterial artificial …
presents a significant problem in the diagnosis and management of human cytomegalovirus
(HCMV) infections. Here we describe a collaborative study to evaluate the suitability of
candidate reference materials to harmonize HCMV viral load measurements in a wide range
of NAT assays. Candidate materials comprised lyophilized Merlin virus, liquid Merlin virus,
liquid AD169 virus, and purified HCMV Merlin DNA cloned into a bacterial artificial …
