A histologic study of the circadian system in Parkinson disease, multiple system atrophy, and progressive supranuclear palsy
E De Pablo-Fernández, R Courtney, TT Warner… - JAMA …, 2018 - jamanetwork.com
Importance Circadian dysfunction may be associated with the symptoms and
neurodegeneration in Parkinson disease (PD), multiple system atrophy (MSA), and
progressive supranuclear palsy (PSP), although the underlying neuroanatomical site of
disruption and pathophysiological mechanisms are not fully understood. Objective To
perform a neuropathological analysis of disease-specific inclusions in the key structures of
the circadian system in patients with PD, MSA, and PSP. Design, Setting, and Participants …
neurodegeneration in Parkinson disease (PD), multiple system atrophy (MSA), and
progressive supranuclear palsy (PSP), although the underlying neuroanatomical site of
disruption and pathophysiological mechanisms are not fully understood. Objective To
perform a neuropathological analysis of disease-specific inclusions in the key structures of
the circadian system in patients with PD, MSA, and PSP. Design, Setting, and Participants …