The capsaicin VR1 receptor mediates substance P release in toxin A-induced enteritis in rats
DC McVey, SR Vigna - Peptides, 2001 - Elsevier
The mechanism by which Clostridium difficile toxin A causes substance P (SP) release and
subsequent inflammation in the rat ileum is unknown. Pretreatment with the vanilloid
receptor subtype 1 (VR1) antagonist, capsazepine, before toxin A administration significantly
inhibited toxin A-induced SP release and intestinal inflammation. Intraluminal administration
of the VR1 agonist capsaicin caused intestinal inflammation similar to the effects of toxin A.
Pretreatment with capsazepine before capsaicin administration also significantly inhibited …
subsequent inflammation in the rat ileum is unknown. Pretreatment with the vanilloid
receptor subtype 1 (VR1) antagonist, capsazepine, before toxin A administration significantly
inhibited toxin A-induced SP release and intestinal inflammation. Intraluminal administration
of the VR1 agonist capsaicin caused intestinal inflammation similar to the effects of toxin A.
Pretreatment with capsazepine before capsaicin administration also significantly inhibited …
