Treatment of refractory diarrhoea in AIDS with acetorphan and octreotide: a randomized crossover study
L Beaugerie, P Baumer, S Chaussade… - European journal of …, 1996 - journals.lww.com
Objective: To compare the efficacy and tolerance of acetorphan, an orally active
enkephalinase inhibitor whose antidiarrhoeal properties derive from a purely antisecretory
activity, to that of octreotide, a subcutaneously administered somatostatin analogue, in the
treatment of refractory diarrhoea in AIDS patients. Design: An open randomized crossover
trial. Setting: The inpatient medical units of three hospitals. Patients: Thirteen adult inpatients
with AIDS and refractory diarrhoea that lasted for 35±8 weeks despite use of traditional …
enkephalinase inhibitor whose antidiarrhoeal properties derive from a purely antisecretory
activity, to that of octreotide, a subcutaneously administered somatostatin analogue, in the
treatment of refractory diarrhoea in AIDS patients. Design: An open randomized crossover
trial. Setting: The inpatient medical units of three hospitals. Patients: Thirteen adult inpatients
with AIDS and refractory diarrhoea that lasted for 35±8 weeks despite use of traditional …
