The efficient cellular uptake of high density lipoprotein lipids via scavenger receptor class B type I requires not only receptor-mediated surface binding but also …
X Gu, B Trigatti, S Xu, S Acton, J Babitt… - Journal of Biological …, 1998 - ASBMB
The class B type I scavenger receptor,(SR-BI), is a member of the CD36 superfamily of
proteins and is a physiologically relevant, high affinity cell surface high density lipoprotein
(HDL) receptor that mediates selective lipid uptake. The mechanism of selective lipid uptake
is fundamentally different from that of classic receptor-mediated uptake via coated pits and
vesicles (eg the low density lipoprotein receptor pathway) in that it involves efficient transfer
of the lipids, but not the outer shell proteins, from HDL to cells. The abilities of SR-BI and …
proteins and is a physiologically relevant, high affinity cell surface high density lipoprotein
(HDL) receptor that mediates selective lipid uptake. The mechanism of selective lipid uptake
is fundamentally different from that of classic receptor-mediated uptake via coated pits and
vesicles (eg the low density lipoprotein receptor pathway) in that it involves efficient transfer
of the lipids, but not the outer shell proteins, from HDL to cells. The abilities of SR-BI and …
