Follicular helper T cells mediate IgE antibody response to airborne allergens
T Kobayashi, K Iijima, AL Dent, H Kita - Journal of Allergy and Clinical …, 2017 - Elsevier
Background TH 2 cells have long been believed to play a pivotal role in allergic immune
responses, including IgE antibody production and type 2 cytokine–mediated inflammation
and pathology. A new T-cell subset, follicular helper T (T FH) cells, is specialized in
supporting B-cell maturation and antibody production. Objective We sought to investigate
the roles of T FH cells in allergic immune responses. Methods Naive mice were exposed to
cytokines or natural allergens through the airways. Development of allergic immune …
responses, including IgE antibody production and type 2 cytokine–mediated inflammation
and pathology. A new T-cell subset, follicular helper T (T FH) cells, is specialized in
supporting B-cell maturation and antibody production. Objective We sought to investigate
the roles of T FH cells in allergic immune responses. Methods Naive mice were exposed to
cytokines or natural allergens through the airways. Development of allergic immune …
