[HTML][HTML] Glucose activates ChREBP by increasing its rate of nuclear entry and relieving repression of its transcriptional activity
MN Davies, BL O'Callaghan, HC Towle - Journal of biological chemistry, 2008 - ASBMB
Carbohydrate response element-binding protein (ChREBP) is a glucose-responsive
transcription factor that activates genes involved in de novo lipogenesis in mammals. The
current model for glucose activation of ChREBP proposes that increased glucose
metabolism triggers a cytoplasmic to nuclear translocation of ChREBP that is critical for
activation. However, we find that ChREBP actively shuttles between the cytoplasm and
nucleus in both low and high glucose in the glucose-sensitive β cell-derived line, 832/13 …
transcription factor that activates genes involved in de novo lipogenesis in mammals. The
current model for glucose activation of ChREBP proposes that increased glucose
metabolism triggers a cytoplasmic to nuclear translocation of ChREBP that is critical for
activation. However, we find that ChREBP actively shuttles between the cytoplasm and
nucleus in both low and high glucose in the glucose-sensitive β cell-derived line, 832/13 …