MicroRNAs have been implicated in ischemic AKI. However, the specific microRNA species
that regulates ischemic kidney injury remains unidentified. Our previous microarray analysis
revealed microRNA-489 induction in kidneys of mice subjected to renal ischemia-
reperfusion. In this study, we verified the induction of microRNA-489 during ischemic AKI in
mice and further examined the underlying mechanisms. Hypoxia–inducible factor–1α
deficiency associated with diminished microRNA-489 induction in cultured rat proximal …