Interferon-inducible Ifi200-family genes in systemic lupus erythematosus

D Choubey, R Panchanathan - Immunology letters, 2008 - Elsevier
Systemic lupus erythematosus (SLE) is the prototype of complex autoimmune diseases.
Studies have suggested that genetic, hormonal, and environmental factors contribute to the
development of the disease. Interestingly, several recent studies involving SLE patients and
mouse models of the disease have suggested a role for interferon (IFN)-stimulated genes
(ISGs) in the development of SLE. One family of ISGs is the Ifi200-family, which includes
mouse (Ifi202a, Ifi202b, Ifi203, Ifi204, and Ifi205) and human (IFI16, MNDA, AIM2, and IFIX) …