[HTML][HTML] Regulation of osteoblast, chondrocyte, and osteoclast functions by fibroblast growth factor (FGF)-18 in comparison with FGF-2 and FGF-10

T Shimoaka, T Ogasawara, A Yonamine… - Journal of Biological …, 2002 - ASBMB
This study investigated the actions of fibroblast growth factor (FGF)-18, a novel member of
the FGF family, on osteoblasts, chondrocytes, and osteoclasts and compared them with
those of FGF-2 and FGF-10. FGF-18 stimulated the proliferation of cultured mouse primary
osteoblasts, osteoblastic MC3T3-E1 cells, primary chondrocytes, and prechondrocytic
ATDC5 cells, although it inhibited the differentiation and matrix synthesis of these cells. FGF-
18 up-regulated the phosphorylation of extracellular signal-regulated kinase in both …