[HTML][HTML] Targeted Proteomic Analysis of 14-3-3ς, a p53 Effector Commonly Silenced in Cancer* S

A Benzinger, N Muster, HB Koch, JR Yates… - Molecular & cellular …, 2005 - ASBMB
To comprehensively identify proteins interacting with 14-3-3ς in vivo, tandem affinity
purification and the multidimensional protein identification technology were combined to
characterize 117 proteins associated with 14-3-3ς in human cells. The majority of identified
proteins contained one or several phosphorylatable 14-3-3-binding sites indicating a
potential direct interaction with 14-3-3ς. 25 proteins were not previously assigned to any
function and were named SIP2–26 (for 14-3-3ς-interacting protein). Among the 92 …