[HTML][HTML] The scaffold MyD88 acts to couple protein kinase Cϵ to Toll-like receptors

A Faisal, A Saurin, B Gregory, B Foxwell… - Journal of biological …, 2008 - ASBMB
Mice lacking protein kinase Cϵ (PKCϵ) are hypersensitive to both Gram-positive and Gram-
negative bacterial infections; however, the mechanism of PKCϵ coupling to the Toll-like
receptors (TLRs), responsible for pathogen detection, is poorly understood. Here we sought
to investigate the mechanism of PKCϵ involvement in TLR signaling and found that PKCϵ is
recruited to TLR4 and phosphorylated on two recently identified sites in response to
lipopolysaccharide (LPS) stimulation. Phosphorylation at both of these sites (Ser-346 and …