[HTML][HTML] Distinct roles for Nod2 protein and autocrine interleukin-1β in muramyl dipeptide-induced mitogen-activated protein kinase activation and cytokine secretion in …

M Hedl, C Abraham - Journal of Biological Chemistry, 2011 - ASBMB
Elucidating factors regulating Crohn's disease-associated nucleotide-binding
oligomerization domain 2 (Nod2) responses is critical to understanding the mechanisms of
intestinal immune homeostasis. Stimulation of primary monocyte-derived macrophages by
muramyl dipeptide (MDP), a component of bacterial peptidoglycan and specific Nod2 ligand,
produces cytokines, including IL-1β. We found that IL-1β blockade profoundly inhibits MDP-
induced cytokine production in human monocyte-derived macrophages, demonstrating a …