Invariant NKT cells promote alcohol-induced steatohepatitis through interleukin-1β in mice

K Cui, G Yan, C Xu, Y Chen, J Wang, R Zhou, L Bai… - Journal of …, 2015 - Elsevier
Background & Aims It was reported that alcohol consumption activated the NLRP3
inflammasome in Kupffer cells, leading to mature interleukin (IL)-1β release in alcoholic liver
injury; however, how IL-1β promotes liver injury remains unclear. Methods We investigated
the role of IL-1β in alcoholic steatohepatitis by using a chronic plus single-binge ethanol
consumption mouse model. Results Here, liver steatosis was accompanied by notably
increased invariant natural killer T (iNKT) cell numbers and activation, and iNKT-deficient …