Association of–3826 G variant in uncoupling protein-1 with increased BMI in overweight Australian women

LK Heilbronn, KL Kind, E Pancewicz, AM Morris… - Diabetologia, 2000 - Springer
LK Heilbronn, KL Kind, E Pancewicz, AM Morris, M Noakes, PM Clifton
Diabetologia, 2000Springer
Aims/hypothesis. To determine whether genetic variation in uncoupling protein-1 (UCP-1) is
associated with obesity or obesity-related risk factors in overweight women.¶ Methods. We
genotyped 526 overweight/obese women (mean body mass index 34.1 kg/m 2, range 25.0
to 47.5 kg/m 2) for the–3826 A→ G uncoupling protein-1 polymorphism. Of the 526 women
genotyped 144 had fasting blood samples analysed for glucose and lipid measurements.¶
Results. The–3826 G allele was found with a frequency of 0.23 and was associated with …
Abstract
Aims/hypothesis. To determine whether genetic variation in uncoupling protein-1 (UCP-1) is associated with obesity or obesity-related risk factors in overweight women.¶Methods. We genotyped 526 overweight/obese women (mean body mass index 34.1 kg/m2, range 25.0 to 47.5 kg/m2) for the –3826 AG uncoupling protein-1 polymorphism. Of the 526 women genotyped 144 had fasting blood samples analysed for glucose and lipid measurements.¶Results. The –3826 G allele was found with a frequency of 0.23 and was associated with higher BMI (p = 0.02). A higher frequency of this polymorphism (0.33) was found in subjects with Type II (non-insulin-dependent) diabetes mellitus (p = 0.02), though adjustment for BMI weakened this significance (p = 0.06). The –3826 G variant was associated with increased fasting glucose (p = 0.01). This was, however, a result of a greater proportion of women with Type II diabetes also having the G variant (p = 0.10, adjusted for Type II diabetes). The –3826 G variant of uncoupling protein-1 did not have an effect on other metabolic variables associated with obesity.¶Conclusion/interpretation. In overweight Australian women the –3826 G variant of UCP-1 increased the susceptibility to obesity indicating that UCP-1 could be involved in weight regulation. [Diabetologia (2000) 43: 242–244]
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