Two variants located in the upstream enhancer region of human UCP1 gene affect gene expression and are correlated with human longevity

G Rose, P Crocco, P D'Aquila, A Montesanto… - Experimental …, 2011 - Elsevier
The brown fat specific UnCoupling Protein 1 (UCP1) is involved in thermogenesis, a process
by which energy is dissipated as heat in response to cold stress and excess of caloric intake.
Thermogenesis has potential implications for body mass control and cellular fat metabolism.
In fact, in humans, the variability of the UCP1 gene is associated with obesity, fat gain and
metabolism. Since regulation of metabolism is one of the key-pathways in lifespan
extension, we tested the possible effects of UCP1 variability on survival. Two polymorphisms …