[HTML][HTML] Complement activation in Glioblastoma multiforme pathophysiology: evidence from serum levels and presence of complement activation products in tumor …
TAM Bouwens, LA Trouw, R Veerhuis… - Journal of …, 2015 - Elsevier
Inflammation plays a key role in the pathophysiology of Glioblastoma Multiforme (GBM).
Here we focus on the contribution of the so far largely ignored complement system. ELISA
and immunohistochemistry were combined to assess levels and localization of critical
components of the initiation-and effector pathways of the complement cascade in sera and
tumor tissue from GBM patients and matched controls. Serum levels of factor-B were
decreased in GBM patients whereas C1q levels were increased. C1q and factor-B deposited …
Here we focus on the contribution of the so far largely ignored complement system. ELISA
and immunohistochemistry were combined to assess levels and localization of critical
components of the initiation-and effector pathways of the complement cascade in sera and
tumor tissue from GBM patients and matched controls. Serum levels of factor-B were
decreased in GBM patients whereas C1q levels were increased. C1q and factor-B deposited …