[HTML][HTML] Activation of short and long chain fatty acid sensing machinery in the ileum lowers glucose production in vivo
M Zadeh-Tahmasebi, FA Duca, BA Rasmussen… - Journal of Biological …, 2016 - ASBMB
Evidence continues to emerge detailing the myriad of ways the gut microbiota influences
host energy homeostasis. Among the potential mechanisms, short chain fatty acids (SCFAs),
the byproducts of microbial fermentation of dietary fibers, exhibit correlative beneficial
metabolic effects in humans and rodents, including improvements in glucose homeostasis.
The underlying mechanisms, however, remain elusive. We here report that one of the main
bacterially produced SCFAs, propionate, activates ileal mucosal free fatty acid receptor 2 to …
host energy homeostasis. Among the potential mechanisms, short chain fatty acids (SCFAs),
the byproducts of microbial fermentation of dietary fibers, exhibit correlative beneficial
metabolic effects in humans and rodents, including improvements in glucose homeostasis.
The underlying mechanisms, however, remain elusive. We here report that one of the main
bacterially produced SCFAs, propionate, activates ileal mucosal free fatty acid receptor 2 to …