Elevated membrane attack complex in human choroid with high risk complement factor H genotypes

RF Mullins, AD Dewald, LM Streb, K Wang… - Experimental eye …, 2011 - Elsevier
Data from human genetics, histopathology, and animal models reveal a major role for the
complement system in the development of age-related macular degeneration (AMD).
Genetic variations in the complement factor H (CFH) gene are associated with an elevated
risk of AMD. In this study we sought to determine whether eyes from donors with a high-risk
genotype (homozygosity for the histidine allele at codon 402) exhibit altered levels of
membrane attack complex (MAC) in the choroid, compared to eyes with a low risk genotype …