Role of interferon α (IFNα)-inducible Schlafen-5 in regulation of anchorage-independent growth and invasion of malignant melanoma cells
E Katsoulidis, E Mavrommatis, J Woodard… - Journal of biological …, 2010 - ASBMB
IFNα exerts potent inhibitory activities against malignant melanoma cells in vitro and in vivo,
but the mechanisms by which it generates its antitumor effects remain unknown. We
examined the effects of interferon α (IFNα) on the expression of human members of the
Schlafen (SLFN) family of genes, a group of cell cycle regulators that mediate growth-
inhibitory responses. Using quantitative RT-real time PCR, we found detectable basal
expression of all the different human SLFN genes examined (SLFN5, SLFN11, SLFN12 …
but the mechanisms by which it generates its antitumor effects remain unknown. We
examined the effects of interferon α (IFNα) on the expression of human members of the
Schlafen (SLFN) family of genes, a group of cell cycle regulators that mediate growth-
inhibitory responses. Using quantitative RT-real time PCR, we found detectable basal
expression of all the different human SLFN genes examined (SLFN5, SLFN11, SLFN12 …
