[HTML][HTML] PLA2R autoantibodies and recurrent membranous nephropathy after transplantation

R Stahl, E Hoxha, K Fechner - New England Journal of Medicine, 2010 - Mass Medical Soc
R Stahl, E Hoxha, K Fechner
New England Journal of Medicine, 2010Mass Medical Soc
To the Editor: Membranous nephropathy is a leading cause of the nephrotic syndrome in
adults. One third of patients have a progressive loss of renal function and reach end-stage
renal disease. 1 Membranous nephropathy recurs in up to 40% of patients after renal
transplantation. 2 Recently, Beck et al. 3 found that patients with membranous nephropathy
had circulating autoantibodies against M-type phospholipase A2 receptor (PLA2R), which in
the kidney is exclusively expressed on glomerular podocytes. Binding of PLA2R …
To the Editor: Membranous nephropathy is a leading cause of the nephrotic syndrome in adults. One third of patients have a progressive loss of renal function and reach end-stage renal disease.1 Membranous nephropathy recurs in up to 40% of patients after renal transplantation.2 Recently, Beck et al.3 found that patients with membranous nephropathy had circulating autoantibodies against M-type phospholipase A2 receptor (PLA2R), which in the kidney is exclusively expressed on glomerular podocytes. Binding of PLA2R autoantibodies to this receptor is responsible for the induction of idiopathic membranous nephropathy.4
We report findings regarding a 56-year-old female patient with biopsy-proven membranous . . .
The New England Journal Of Medicine