Prevalence and phylogenetic history of the TcpC virulence determinant in Escherichia coli
S Schubert, D Nörenberg, O Clermont… - International Journal of …, 2010 - Elsevier
Extraintestinal pathogenic Escherichia coli (ExPECs) possess an armament of virulence
factors to colonize and infect the host, such as adhesins, toxins, capsules and iron-uptake
systems. Recently, we could identify a novel virulence factor of ExPECs that interferes with
the innate immune response of the host by interrupting the NF-κB signaling pathway. This
protein named TcpC shows considerable homology to motifs of the Tir domain of Toll-like
receptors. Here we demonstrate that the tcpC gene is widely distributed among clinical …
factors to colonize and infect the host, such as adhesins, toxins, capsules and iron-uptake
systems. Recently, we could identify a novel virulence factor of ExPECs that interferes with
the innate immune response of the host by interrupting the NF-κB signaling pathway. This
protein named TcpC shows considerable homology to motifs of the Tir domain of Toll-like
receptors. Here we demonstrate that the tcpC gene is widely distributed among clinical …