[HTML][HTML] Crystal structures of the Toll/Interleukin-1 receptor (TIR) domains from the Brucella protein TcpB and host adaptor TIRAP reveal mechanisms of molecular …
GA Snyder, D Deredge, A Waldhuber… - Journal of Biological …, 2014 - ASBMB
The Toll/IL-1 receptor (TIR) domains are crucial innate immune signaling modules. Microbial
TIR domain-containing proteins inhibit Toll-like receptor (TLR) signaling through molecular
mimicry. The TIR domain-containing protein TcpB from Brucella inhibits TLR signaling
through interaction with host adaptor proteins TIRAP/Mal and MyD88. To characterize the
microbial mimicry of host proteins, we have determined the X-ray crystal structures of the TIR
domains from the Brucella protein TcpB and the host adaptor protein TIRAP. We have further …
TIR domain-containing proteins inhibit Toll-like receptor (TLR) signaling through molecular
mimicry. The TIR domain-containing protein TcpB from Brucella inhibits TLR signaling
through interaction with host adaptor proteins TIRAP/Mal and MyD88. To characterize the
microbial mimicry of host proteins, we have determined the X-ray crystal structures of the TIR
domains from the Brucella protein TcpB and the host adaptor protein TIRAP. We have further …