[HTML][HTML] Nuclear targeting of 6-phosphofructo-2-kinase (PFKFB3) increases proliferation via cyclin-dependent kinases
A Yalcin, BF Clem, A Simmons, A Lane… - Journal of Biological …, 2009 - ASBMB
The regulation of metabolism and growth must be tightly coupled to guarantee the efficient
use of energy and anabolic substrates throughout the cell cycle. Fructose 2, 6-bisphosphate
(Fru-2, 6-BP) is an allosteric activator of 6-phosphofructo-1-kinase (PFK-1), a rate-limiting
enzyme and essential control point in glycolysis. The concentration of Fru-2, 6-BP in
mammalian cells is set by four 6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatases
(PFKFB1–4), which interconvert fructose 6-phosphate and Fru-2, 6-BP. The relative …
use of energy and anabolic substrates throughout the cell cycle. Fructose 2, 6-bisphosphate
(Fru-2, 6-BP) is an allosteric activator of 6-phosphofructo-1-kinase (PFK-1), a rate-limiting
enzyme and essential control point in glycolysis. The concentration of Fru-2, 6-BP in
mammalian cells is set by four 6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatases
(PFKFB1–4), which interconvert fructose 6-phosphate and Fru-2, 6-BP. The relative …