[PDF][PDF] In epigenetic therapy, less is more
In Epigenetic Therapy, Less Is More Page 1 Hu, Y., Chen, Y., Douglas, L., and Li, S. (2009).
Leukemia 23, 109–116. Li, L., Wang, L., Li, L., Wang, Z., Ho, Y., McDonald, T., Holyoake, TL,
Chen, W., and Bhatia, R. (2012). Cancer Cell 21, 266–281. Wang, Y., Krivtsov, AV, Sinha, AU,
North, TE, Goessling, W., Feng, Z., Zon, LI, and Armstrong, SA (2010). Science 327,
1650–1653. Weisberg, E., Manley, PW, Cowan-Jacob, SW, Hochhaus, A., and Griffin, JD (2007).
Nat. Rev. Cancer 7, 345–356. Zhang, B., Strauss, AC, Chu, S., Li, M., Ho, Y., Shiang, KD …
Leukemia 23, 109–116. Li, L., Wang, L., Li, L., Wang, Z., Ho, Y., McDonald, T., Holyoake, TL,
Chen, W., and Bhatia, R. (2012). Cancer Cell 21, 266–281. Wang, Y., Krivtsov, AV, Sinha, AU,
North, TE, Goessling, W., Feng, Z., Zon, LI, and Armstrong, SA (2010). Science 327,
1650–1653. Weisberg, E., Manley, PW, Cowan-Jacob, SW, Hochhaus, A., and Griffin, JD (2007).
Nat. Rev. Cancer 7, 345–356. Zhang, B., Strauss, AC, Chu, S., Li, M., Ho, Y., Shiang, KD …
How DNA methylation inhibitors exert their anticancer effects in patients is not well understood. In the latest issue of Cancer Cell, Tsai et al. (2012) use low-dose drug treatment to induce persistent attenuation of tumorigenicity by targeting tumor-initiating cells.
cell.com