[HTML][HTML] HDL-mediated cholesterol uptake and targeting to lipid droplets in adipocytes
Adipocytes express high levels of the HDL scavenger receptor class B type I in a
differentiation-dependent manner. We thus have analyzed the routes of HDL cholesterol
trafficking at different phases of adipocyte differentiation in the 3T3-L1 cell line. One novel
and salient feature of this paper is the observation of a widespread distribution in the cell
cytoplasm of Golgi markers, caveolin-2, and a fluorescent cholesterol analog NBD-
cholesterol (NBD-chol), observed in the early phases of adipocyte formation, clearly distinct …
differentiation-dependent manner. We thus have analyzed the routes of HDL cholesterol
trafficking at different phases of adipocyte differentiation in the 3T3-L1 cell line. One novel
and salient feature of this paper is the observation of a widespread distribution in the cell
cytoplasm of Golgi markers, caveolin-2, and a fluorescent cholesterol analog NBD-
cholesterol (NBD-chol), observed in the early phases of adipocyte formation, clearly distinct …