[HTML][HTML] Differential modulation of Toll-like receptors by fatty acids: preferential inhibition by n-3 polyunsaturated fatty acids
Human subjects consuming fish oil showed a significant suppression of cyclooxygenase-2
(COX-2) expression in blood monocytes when stimulated in vitro with lipopolysaccharide
(LPS), an agonist for Toll-like receptor 4 (TLR4). Results with a murine monocytic cell line
(RAW 264.7) stably transfected with COX-2 promoter reporter gene also demonstrated that
LPS-induced COX-2 expression was preferentially inhibited by docosahexaenoic acid
(DHA, C22: 6n-3) and eicosapentaenoic acid (EPA, C20: 5n-3), the major n-3 …
(COX-2) expression in blood monocytes when stimulated in vitro with lipopolysaccharide
(LPS), an agonist for Toll-like receptor 4 (TLR4). Results with a murine monocytic cell line
(RAW 264.7) stably transfected with COX-2 promoter reporter gene also demonstrated that
LPS-induced COX-2 expression was preferentially inhibited by docosahexaenoic acid
(DHA, C22: 6n-3) and eicosapentaenoic acid (EPA, C20: 5n-3), the major n-3 …