[HTML][HTML] Inflammatory remodeling of the HDL proteome impairs cholesterol efflux capacity [S]
T Vaisar, C Tang, I Babenko, P Hutchins… - Journal of lipid …, 2015 - ASBMB
Recent studies demonstrate that HDL's ability to promote cholesterol efflux from
macrophages associates strongly with cardioprotection in humans independently of HDL-
cholesterol (HDL-C) and apoA-I, HDL's major protein. However, the mechanisms that impair
cholesterol efflux capacity during vascular disease are unclear. Inflammation, a well-
established risk factor for cardiovascular disease, has been shown to impair HDL's
cholesterol efflux capacity. We therefore tested the hypothesis that HDL's impaired efflux …
macrophages associates strongly with cardioprotection in humans independently of HDL-
cholesterol (HDL-C) and apoA-I, HDL's major protein. However, the mechanisms that impair
cholesterol efflux capacity during vascular disease are unclear. Inflammation, a well-
established risk factor for cardiovascular disease, has been shown to impair HDL's
cholesterol efflux capacity. We therefore tested the hypothesis that HDL's impaired efflux …