[HTML][HTML] Phosphoenolpyruvate carboxykinase overexpression selectively attenuates insulin signaling and hepatic insulin sensitivity in transgenic mice
Y Sun, S Liu, S Ferguson, LQ Wang, P Klepcyk… - Journal of Biological …, 2002 - ASBMB
The ability of insulin to suppress gluconeogenesis in type II diabetes mellitus is impaired;
however, the cellular mechanisms for this insulin resistance remain poorly understood. To
address this question, we generated transgenic (TG) mice overexpressing the
phosphoenolpyruvate carboxykinase (PEPCK) gene under control of its own promoter. TG
mice had increased basal hepatic glucose production (HGP), but normal levels of plasma
free fatty acids (FFAs) and whole-body glucose disposal during a hyperinsulinemic …
however, the cellular mechanisms for this insulin resistance remain poorly understood. To
address this question, we generated transgenic (TG) mice overexpressing the
phosphoenolpyruvate carboxykinase (PEPCK) gene under control of its own promoter. TG
mice had increased basal hepatic glucose production (HGP), but normal levels of plasma
free fatty acids (FFAs) and whole-body glucose disposal during a hyperinsulinemic …