Equilibrium relations between pyridine nucleotides and adenine nucleotides and their roles in the regulation of metabolic processes
HA Krebs, RL Veech - Advances in enzyme regulation, 1969 - Elsevier
The differences between the redox states of the NAD-and NADP-couples in the cytoplasm
have been measured. The ratio [free NADP]/[free NADPH 2] was found to be about 100,000
times smaller than the ratio [free NAD]/[NADH 2]. These differences can be explained on the
basis of simple physicochemical principles. They are essentially the result of thermodynamic
equilibria. The position of these depends on the equilibrium constants of a number of highly
active, readily reversible enzymes and the concentration of the substrates and products of …
have been measured. The ratio [free NADP]/[free NADPH 2] was found to be about 100,000
times smaller than the ratio [free NAD]/[NADH 2]. These differences can be explained on the
basis of simple physicochemical principles. They are essentially the result of thermodynamic
equilibria. The position of these depends on the equilibrium constants of a number of highly
active, readily reversible enzymes and the concentration of the substrates and products of …