[HTML][HTML] Hsp70 and Hsp90 multichaperone complexes sequentially regulate thiazide-sensitive cotransporter endoplasmic reticulum-associated degradation and …
BF Donnelly, PG Needham, AC Snyder, A Roy… - Journal of Biological …, 2013 - ASBMB
The thiazide-sensitive NaCl cotransporter (NCC) is the primary mediator of salt reabsorption
in the distal convoluted tubule and is a key determinant of the blood pressure set point.
Given its complex topology, NCC is inefficiently processed and prone to endoplasmic
reticulum (ER)-associated degradation (ERAD), although the mechanisms governing this
process remain obscure. Here, we identify factors that impact the ER quality control of NCC.
Analyses of NCC immunoprecipitates revealed that the cotransporter formed complexes with …
in the distal convoluted tubule and is a key determinant of the blood pressure set point.
Given its complex topology, NCC is inefficiently processed and prone to endoplasmic
reticulum (ER)-associated degradation (ERAD), although the mechanisms governing this
process remain obscure. Here, we identify factors that impact the ER quality control of NCC.
Analyses of NCC immunoprecipitates revealed that the cotransporter formed complexes with …