[HTML][HTML] Regulation of the Na+-Cl− cotransporter by dietary NaCl: a role for WNKs, SPAK, OSR1, and aldosterone
V Vallon - Kidney international, 2008 - Elsevier
Kidney international, 2008•Elsevier
This Commentary aims to integrate or interrelate the available data with the current study by
Chiga and co-workers, which defines an important influence of aldosterone in the
phosphorylation and thus activation of the Na+-Cl− cotransporter (NCC) in response to
changes in NaCl intake and implicates the involvement of SPAK/OSR1 kinases and WNKs.
Chiga and co-workers, which defines an important influence of aldosterone in the
phosphorylation and thus activation of the Na+-Cl− cotransporter (NCC) in response to
changes in NaCl intake and implicates the involvement of SPAK/OSR1 kinases and WNKs.
This Commentary aims to integrate or interrelate the available data with the current study by Chiga and co-workers, which defines an important influence of aldosterone in the phosphorylation and thus activation of the Na+-Cl− cotransporter (NCC) in response to changes in NaCl intake and implicates the involvement of SPAK/OSR1 kinases and WNKs.
Elsevier