[HTML][HTML] cAMP and serum and glucocorticoid-inducible kinase (SGK) regulate the epithelial Na+ channel through convergent phosphorylation of Nedd4-2
PM Snyder, DR Olson, R Kabra, R Zhou… - Journal of Biological …, 2004 - ASBMB
The epithelial Na+ channel (ENaC) functions as a pathway for epithelial Na+ transport,
contributing to Na+ homeostasis and blood pressure control. Vasopressin increases ENaC
expression at the cell surface through a pathway that includes cAMP and cAMP-dependent
protein kinase (PKA), but the mechanisms that link PKA to ENaC are unknown. Here we
found that cAMP regulates Na+ transport in part by inhibiting the function of Nedd4-2, an E3
ubiquitin-protein ligase that targets ENaC for degradation. Consistent with this model, we …
contributing to Na+ homeostasis and blood pressure control. Vasopressin increases ENaC
expression at the cell surface through a pathway that includes cAMP and cAMP-dependent
protein kinase (PKA), but the mechanisms that link PKA to ENaC are unknown. Here we
found that cAMP regulates Na+ transport in part by inhibiting the function of Nedd4-2, an E3
ubiquitin-protein ligase that targets ENaC for degradation. Consistent with this model, we …