[HTML][HTML] Neural precursor cell-expressed developmentally down-regulated protein 4-2 (Nedd4-2) regulation by 14-3-3 protein binding at canonical serum and …
S Chandran, H Li, W Dong, K Krasinska… - Journal of Biological …, 2011 - ASBMB
Regulation of epithelial Na+ channel (ENaC)-mediated transport in the distal nephron is a
critical determinant of blood pressure in humans. Aldosterone via serum and glucocorticoid
kinase 1 (SGK1) stimulates ENaC by phosphorylation of the E3 ubiquitin ligase Nedd4-2,
which induces interaction with 14-3-3 proteins. However, the mechanisms of SGK1-and 14-3-
3-mediated regulation of Nedd4-2 are unclear. There are three canonical SGK1 target sites
on Nedd4-2 that overlap phosphorylation-dependent 14-3-3 interaction motifs. Two of these …
critical determinant of blood pressure in humans. Aldosterone via serum and glucocorticoid
kinase 1 (SGK1) stimulates ENaC by phosphorylation of the E3 ubiquitin ligase Nedd4-2,
which induces interaction with 14-3-3 proteins. However, the mechanisms of SGK1-and 14-3-
3-mediated regulation of Nedd4-2 are unclear. There are three canonical SGK1 target sites
on Nedd4-2 that overlap phosphorylation-dependent 14-3-3 interaction motifs. Two of these …