The distal convoluted tubule is the nephron segment that lies immediately downstream of
the macula densa. Although short in length, the distal convoluted tubule plays a critical role
in sodium, potassium, and divalent cation homeostasis. Recent genetic and physiologic
studies have greatly expanded our understanding of how the distal convoluted tubule
regulates these processes at the molecular level. This article provides an update on the
distal convoluted tubule, highlighting concepts and pathophysiology relevant to clinical …